first two patches: http://trac.wxwidgets.org/ticket/15462
the rest is to make gtk work and for proper handling of arch & sdk flags
--- config.py.orig
+++ config.py
@@ -722,6 +722,7 @@ def _darwin_compiler_fixup(compiler_so, cc_args):
     build, without a way to remove an architecture. Furthermore GCC will
     barf if multiple '-isysroot' arguments are present.
     """
+    from distutils import log
     stripArch = stripSysroot = 0
 
     compiler_so = list(compiler_so)
@@ -765,9 +766,9 @@ def _darwin_compiler_fixup(compiler_so, cc_args):
         sysroot = compiler_so[idx+1]
 
     if sysroot and not os.path.isdir(sysroot):
-        log.warn("Compiling with an SDK that doesn't seem to exist: %s",
+        log.warning("Compiling with an SDK that doesn't seem to exist: %s",
                 sysroot)
-        log.warn("Please check your Xcode installation")
+        log.warning("Please check your Xcode installation")
 
     return compiler_so
 
@@ -1024,27 +1025,16 @@ elif os.name == 'posix' or COMPILER == 'mingw32':
     WXRELEASE  = os.popen(WX_CONFIG + ' --release').read()[:-1]
     WXPREFIX   = os.popen(WX_CONFIG + ' --prefix').read()[:-1]
 
-
-    if sys.platform[:6] == "darwin" and WXPORT == 'mac':
+    if sys.platform[:6] == "darwin":
+        libs = ['stdc++']
+        NO_SCRIPTS = 1
+        # @@FLAGS1@@
+        # @@FLAGS2@@
+        # @@FLAGS3@@
+    if WXPORT == 'mac':
         # Flags and such for a Darwin (Max OS X) build of Python
         WXPLAT = '__WXMAC__'
         GENDIR = 'mac'
-        libs = ['stdc++']
-        NO_SCRIPTS = 1
-        if not ARCH == "":
-            cflags.append("-arch")
-            cflags.append(ARCH)
-            lflags.append("-arch")
-            lflags.append(ARCH)
-            #if ARCH == "ppc":
-            #    cflags.append("-isysroot")
-            #    cflags.append("/Developer/SDKs/MacOSX10.3.9.sdk")
-
-        if not os.environ.get('CC') or not os.environ.get('CXX'):
-            os.environ["CXX"] = "g++-4.0"
-            os.environ["CC"]  = "gcc-4.0"
-            os.environ["CPP"] = "cpp-4.0"
-
     else:
         # Set flags for other Unix type platforms
         GENDIR = WXPORT
@@ -1070,14 +1060,6 @@ elif os.name == 'posix' or COMPILER == 'mingw32':
 
         cflags += portcfg.split()
 
-        # Some distros (e.g. Mandrake) put libGLU in /usr/X11R6/lib, but
-        # wx-config doesn't output that for some reason.  For now, just
-        # add it unconditionally but we should really check if the lib is
-        # really found there or wx-config should be fixed.
-        if WXPORT != 'msw':
-            libdirs.append("/usr/X11R6/lib")
-
-
     # Move the various -I, -D, etc. flags we got from the *config scripts
     # into the distutils lists.
     cflags = adjustCFLAGS(cflags, defines, includes)